Results
| PMID | 14562641 |
| Gene Name | IL10 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | IL-10 (-627 gene promoter polymorphism) |
| Population size | 263 |
| Population details | 263 (130 endometriosis, 133 non endometriosis) |
| Sex | Female |
| Associated genes | IL-10 |
| Other associated phenotypes |
Endometriosis |
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J Reprod Med. 2003 Sep;48(9):735-8. Hsieh, Yao-Yuan| Chang, Chi-Chen| Tsai, Fuu-Jen| Lin, Cheng-Chieh| Tai, Chin-Tao| Ho, Min Departments of Obstetrics and Gynecology, of Pediatrics and Medical Genetics and of Family Medicine, China Medical College Hospital, Taichung, Taiwan. OBJECTIVE: To investigate whether interleukin-10 (IL-10) -627 gene promoter polymorphism could be used as a marker of susceptibility to endometriosis. STUDY DESIGN: Women were divided into 2 groups, endometriosis (n = 130) and nonendometriosis (n = 133). Polymorphisms for IL-10 -627 gene promoter were amplified by polymerase chain reaction and detected after restriction enzyme digestion. Genotypes and allelic frequencies in both groups were compared. RESULTS: Genotype proportions of different IL-10 gene polymorphisms in both groups were not significantly different. Proportions of A homozygote/heterozygote/T homozygote for IL-10 gene polymorphisms in both groups were 50%/40%/10% and 42.1%/38.4%/19.5%. In contrast, allele frequencies for IL-10 gene polymorphism between both groups were significantly different. Alleles A and C for IL-10 gene promoter polymorphism in the groups were 70%/30% and 61.3%/38.7%. A allele was associated with higher susceptibility to endometriosis. CONCLUSION: An association between endometriosis and IL-10 gene promoter polymorphism exists, and the IL-10 -627 A allele is related to a higher susceptibility to endometriosis. Mesh Terms: *Alleles| Deoxyribonucleases, Type II Site-Specific/metabolism| Endometriosis/*genetics| Female| Gene Frequency| *Genetic Predisposition to Disease| Heterozygote| Homozygote| Humans| Interleukin-10/*genetics| *Polymorphism, Genetic| Premenopaus |
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